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Origins 2011 – Abstracts

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L0: Opening Plenary Lecture: Ada Yonath, Nobel Laureate 2009
Time: Sunday, 03/Jul/2011: 4:30pm - 5:30pm
Session Chair: William Irvine
Session Chair: Janet Siefert
Location: Auditorium Pasteur


An RNA apparatus with ribozyme capabilities is embedded and functions within the contemporary ribosome

Ada Yonath

Weizmann Institute, Israel

Peptide bonds are formed by ribosomes, the universal cellular machines for genetic code translating to proteins, is located within a highly conserved internal symmetrical region, composed of RNA. The elaborate architecture of this region positions the tRNA substrates in stereochemistry appropriate for peptide bond formation, for substrate translocation and for directing the nascent proteins into their exit tunnels. Attempts for proving this assumption will be discussed.