Origins 2011 – Abstracts
For registered participants only: more information (and extended abstracts of presentations) is available online in your Origins 2011 ConfTool account (after login follow link "browse conference agenda").
Back to Schedule Overview|
O1b: Contributed Orals – Origins: From Stars to Life (continued)
The Chemical Origins of Nucleotides
1Howard Hughes Medical Institute, Massachusetts General Hospital, USA; 2MRC Laboratory of Molecular Biology, Cambridge University, UK
We reported a chemoselective, prebiotically plausible route to activated canonical pyrimidine ribonucleotides. Development of our chemistry resulted in the discovery of a pH-controlled multicomponent reaction (allowing the first chemoselective glycosylation of purine precursors) and an acyl-transfer cascade (a potential solution to RNA linkage heterogeneity). The bimolecular and multicomponent incorporation of sulfur and the possible implications for RNA and DNA synthesis will be presented.